BTRC Conversations: The Fight Against Brain Tumours
Step into the groundbreaking world of the Arthur and Sonia Labatt Brain Tumour Research Centre (BTRC), where researchers from SickKids and the University Health Network (UHN) unite to tackle the complexities of human brain tumours. More than just a research center, the BTRC is driven by the ambitious goals of not only treating children and adults with brain tumours but also achieving more predictable clinical control over this challenging condition. Delving deep into the molecular roots of brain tumour progression, the BTRC fosters a vibrant, collaborative research ecosystem. With a diverse array of specialized labs and a network of affiliations spanning hospitals, philanthropic organizations, and research institutions, the BTRC stands at the forefront of brain tumour research, fueled by a shared commitment to conquering these devastating illnesses.
BTRC Conversations: The Fight Against Brain Tumours
Episode 1: Targeting Brain Tumour Stem Cells
The lab of Peter Dirks investigates how medulloblastoma stem cells transition from a dormant state to an active, proliferative state, a process regulated by the transcription factor Olig2. The scientists found that inactivating Olig2 prevents stem cell activation, thereby blocking tumour growth. Targeting Olig2 with a small molecule inhibitor, CT-179, significantly slowed early tumour formation and regrowth after therapy in a mouse model. Further analysis revealed the drug effectively limits the ability of the quiescent stem cells to transition to a proliferative state. The study suggests that therapies targeting this stem cell fate transition could improve medulloblastoma treatment outcomes, especially in high-risk cases. The findings provide a basis for developing new treatments targeting cancer stem cell activation and limiting patient tumour progression.
Research funding for pediatric brain tumours is at an all-time low. Please consider donating to the Brain Tumour Research Centre at SickKids (be sure to select "For a specific area or purpose" when prompted at this link: https://www.sickkids.ca/en/care-services/centres/brain-tumour-research-centre/#support
Dr Christian Smith: https://www.scientistandthepsychic.com/